SAF-B Monoclonal Antibody - RA11971

SAF-B Monoclonal Antibody Size: 50μL, 100μL Catalogue Numbers: RA11971-50, RA11971-100 Citations, Manuals and MSDS Available upon request. Background: scaffold attachment factor B (SAFB) Homo sapiens This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA) . This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript v Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. Storage Instructions: -20°C/1 year Applications: WB Species Cross-Reactivity: Human GeneID (Human): 6294 SWISS: Q15424 Source: Mouse Research Use Only