Product Description

SALL4 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66220-50, MB66220-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Members of the SALL gene family encode putative zinc finger transcription factors highly expressed during development . Sall4 is expressed very early in development with other pluripotency regμlators, such as Oct-4 and Nanog . Recent studies suggest Sall4 works as a master regμlator that controls its own expression and the expression of Oct-4 in a transcriptional regμlation feedback loop governing stem cell pluripotency and stem cell fate (2, 3). Immunohistochemical studies indicate that Sall4 is a sensitive and specific diagnostic marker for primary germ cell tumors and yolk sac tumors (4, 5). Research studies have shown that Sall4 is constitutively expressed in acute myeloid leukemia (AML) and is a probable effector of the Wnt/β-catenin signaling pathway in this disease . In addition, mutations in Sall4 have been implicated in human malformation syndromes including Duane-radial ray syndrome (Okihiro syndrome) and Acro-renal-ocμlar syndrome

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC

Alternate Names: ZNF797, Sal-like protein 4, Zinc finger protein 797, Zinc finger protein SALL4

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human SALL4. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of SALL4 protein.

Molecular Weight: ~ 112 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UJQ4

Product: Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.

Research Use Only