Product Description

SAMHD1 Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB67302-25, MB67302-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SAM domain and HD domain-containing protein 1 (SAMHD1) is a negative regμlator of the cell-intrinsic innate immune response. Research studies have identified mutations in SAMHD1 as a cause of Aicardi-Goutieres syndrome, an autoimmune disease characterized by elevated production of interferon-α and symptoms resembling congenital viral infection. SAMHD1 was identified as the restriction factor that renders most myeloid cells refractory to human immunodeficiency virus (HIV) infection. Expression of the viral protein Vpx in refractory cells targets SAMHD1 for ubiquitin-mediated degradation and relieves HIV restriction. SAMHD1 prevents autoimmunity and HIV infection by hydrolyzing intracellμlar deoxynucleoside triphosphates (dNTPs), thereby limiting inappropriate immune activation by self nucleic acid and inhibiting reverse transcription of the HIV genome.

Category: Primary Antibody

Reactivity: Human, Monkey

Host: Mouse

Applications: FC, IF, IHC, WB

Alternate Names: CHBL2, DCIP, HDDC1, MOP-5, SBBI88

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Fμll length human recombinant protein of human SAMHD1(NP_056289) produced in HEK293T cell.

Dilution: WB 1:200~500, IHC 1:150, IF 1:100, FLOW 1:100

Purification: Purified from mouse ascites fluids or tissue cμlture supernatant by affinity chromatography (protein A/G)

Specificity: SAMHD1 Mouse monoclonal antibody detects endogenous levels of SAMHD1 protein.

Molecular Weight: ~ 72 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y3Z3

Product: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Research Use Only