Product Description

SAP49 Polyclonal Antibody

Catalogue Numbers: BS62486-50, BS62486-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15427

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200

Background: SF3B4 is part of the SF3b complex which associates with the U2 snRNP component of the spliceosome and is essential for spliceosome assembly. SF3B4 can associate with BMPR-1A to inhibit BMP-mediated cell differentiation. Haploinsufficiency of SF3B4 has been described in Nager syndrome, a disease of craniofacial malformation condition. Increased copy number of SF3B4 has been shown to play a role in hepatocellular carcinoma progression.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SAP49 polyclonal antibody detects endogenous levels of SAP49 protein.

Extra Notes: Western blot (WB) analysis of SAP49 polyclonal antibody at 1:500 dilution
LaneA:L02 whole cell lysate
LaneB:A549 whole cell lysate
LaneC:HEK293T whole cell lysate
LaneD:CT26 whole cell lysate
LaneE:PC12 whole cell lysate

Bioworld Molecular Weight: ~ 49 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Splicing factor 3B subunit 4; Pre-mRNA-splicing factor SF3b 49 kDa subunit; Spliceosome-associated protein 49; SAP 49; SF3B4; SAP49

Immunogen: Synthetic peptide, corresponding to Human SAP49.

Conjugate: Unconjugated

Modification: Unmodified