Product Description

SARM1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34730-50, RA34730-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: caution:Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method., function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation., similarity:Contains 1 TIR domain., similarity:Contains 2 SAM (sterile alpha motif) domains., subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function., tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 79

Protein Molecular Weight (kDa): 79

Storage: -20°C/1 year

Human Gene ID: 23098

Human SwissProt Number: Q6SZW1

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only