Product Description

SATB2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65709-50, BS65709-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SATB2 is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regμlating skeletal development and osteoblast differentiation. Highly expressed in adμlt and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regμlate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Cow, Horse, Sheep

Host: Rabbit

Applications: FCM

Alternate Names: DNA binding protein SATB2, DNA-binding protein SATB2, FLJ21474, FLJ32076, KIAA1034, MGC119474, MGC119477, SATB family member 2, SATB homeobox 2, SATB2, SATB2_HUMAN, Special AT rich sequence binding protein 2, Special AT-rich sequence-binding protein 2.  

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human SATB2:451-485/733

Dilution: Flow-Cyt=1ug/test

Purification: affinity purified by Protein A

Specificity: SATB2 Polyclonal Antibody detects endogenous levels of SATB2 protein.

Molecular Weight: 83kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UPW6

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only