SCIN Monoclonal Antibody-MB11572

SCIN Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11572-50, MB11572-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9Y6U3

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) . In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts . Regulates chondrocyte proliferation and differentiation . Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 80 kDa; Observed MW: 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SCIN in Hela lysates using SCIN antibody., Immunohistochemistry analysis of paraffin-embedded Human colon cancer using SCIN antibody. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.

Alternative Name: Scinderin

Immunogen: A synthetic peptide of human SCIN

Conjugate: Unconjugated

Modification: Unmodified