Sck rabbit pAb - ES5437

Sck rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5437-50, ES5437-100

Citations, Manuals and MSDS Available upon request.

Background: domain:The PID domain mediates binding to the TrkA receptor., function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons., miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576., PTM:Phosphorylated on tyrosines by the Trk receptors., similarity:Contains 1 PID domain., similarity:Contains 1 SH2 domain., subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2., tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,

Alternate Name: SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 59kD

Human Gene ID: 25759

Human SWISS Prot NO: P98077

Subcellular Location: intracellular, cytosol, plasma membrane,

Research Use Only