Sclerostin rabbit pAb - ES6491

Sclerostin rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6491-50, ES6491-100

Citations, Manuals and MSDS Available upon request.

Background: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008],

Alternate Name: SOST; Sclerostin

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from Sclerostin . at AA range: 130-210

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 26kD

Human Gene ID: 50964

Human SWISS Prot NO: Q9BQB4

Subcellular Location: Secreted, extracellular space, extracellular matrix.

Research Use Only