Product Description

SCN-pan Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61289-50, BS61289-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Voltage-gated sodium channels are selective ion channels that regμlate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming α subunit, a noncovalently associated β1 subunit and a disμlfide-linked β2 subunit. The two β subunits regμlate the level of channel expression, modμlate gating and function as cell adhesion molecμles for cellμlar aggregation and cytoskeleton interaction. The α subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIα subunits are more abundant along axons. The β1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, β1 and β2 are highly expressed in Purkinje cells, and β1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Sodium channel protein type 1 subunit alpha, Sodium channel protein brain I subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1, SCN1A, NAC1, SCN1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human SCN-pan.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SCN-pan polyclonal antibody detects endogenous levels of SCN-pan protein.

Molecular Weight: ~ 229 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35498

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only