Product Description

SCT Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60409-50, BS60409-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Secretin is a 27-amino acid hormone produced by specific endocrine cells, S cells, located in the mucosa of the proximal small intestine. Secretin is known to be a potent stimμlus for the secretion of bicarbonate-rich pancreatic juice. Secretion of secretin is stimμlated by the presence of either acidic pH or fatty acids in the duodenum. Secretin is synthesized as a larger precursor. The deduced amino acid sequence includes a signal peptide, an amino-terminal peptide, secretin itself, and a 72-amino acid carboxy-terminal peptide. Secretin stimμlates ductal bile secretion by directly interacting with cholangiocytes. It stimμlates exocytosis in cholangiocytes, which transport water mainly via the water channel aquaporin-1. Secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone coμld have a neuroendocrine function in addition to its role in digestion. The gene which encodes secretin maps to human chromosome 11p15.5.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Secretin, SCT

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human SCT.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SCT polyclonal antibody detects endogenous levels of SCT protein.

Molecular Weight: ~ 278 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P09683

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only