Product Description

SDCBP (Syntenin) Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4016-25, MB4016-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Syntenin-1 (MDA9, SDCBP) is a member of the PDZ family of proteins, defined by the presence of a PDZ protein interaction domain. Syntenin-1, via its PDZ domain, functions as a scaffold adaptor protein that regμlates numerous signal transduction pathways, including FAK, Src, TGFβR1, EGFR, and IGF1R. Aberrantly elevated expression of syntenin-1 has been found in various cancers, and has been linked to growth and invasion of tumor cells. In the central nervous system, syntenin-1 has been shown to mediate neuron dendrite protrusion and spine formation through its interaction with syndecan and Rheb. Syntenin-1 is also a key component of the syndecan/syntenin/ALIX pathway which has been shown to directly contribute to the formation and internalization of exosomes.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: IHC, WB

Alternate Names: Syntenin-1, Melanoma differentiation-associated protein 9 (MDA-9), Pro-TGF-alpha cytoplasmic domain-interacting protein 18 (TACIP18), Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Fμll length human recombinant protein of human SDCBP(NP_005616) produced in HEK293T cell.

Dilution: WB 1:500~2000, IHC 1:150

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG1

Molecular Weight: ~ 32 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00560

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only