Securin Polyclonal Antibody
Product: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sizes: 50µl, 100µl
Catalogue Numbers: BZ16895-50, BZ16895-100
Swiss-Prot: O95997/Q6IAL9
Host: Rabbit
Reactivity: Human
Applications: WB, IHC-P, ICC/IF, IP, FC
All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100
Background: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: IgG
Calculated MW: 22 kDa; Observed MW: 28 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Securin in HeLa lysates using Securin antibody.
Alternative Name: PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG
Immunogen: A synthesized peptide derived from human Securin
Conjugate: Unconjugated
Modification: Unmodified