SELH Rabbit Polyclonal Antibody - RA29712

SELH Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29712-50, RA29712-100 Citations, Manuals and MSDS Available upon request. Background: This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: WB 1：500-2000 Applications: WB Species Cross-Reactivity: Human; Mouse GeneID (Human): 280636 SWISS: Q8IZQ5 Source: Rabbit Research Use Only