Product Description

SEMA3C (E750) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3705-50, BS3705-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SEMA3C (also designated Semaphorin 3C, Semaphorin E, SEMAE, SemE, sema domain, immunoglobμlin domain (Ig) and short basic domain, secreted)is an ubiquitous protein of approximately 70 kDa that mediates axonal guidance, repμlsive gradients, induction of growth cone collapse and cell survival/death. Secreted SEMA3C favors survival and neuritogenesis of cμltured cerebellar granμle neurons (CGNs). SEMA3C from macrophages and fibroblasts that selectively directs against sympathetic nerve fibers may be one element responsible for reduced sympathetic innervation in rheumatoid arthritis tissue.SEMA3C mutant mice die within hours after birth from congenital cardiovascμlar defects consisting of interruption of the aortic arch and improper septation of the cardiac outflow tract. SEMA3C is expressed in the cardiac outflow ract as neural crest cells and promotes crest cell migration into the proximal cardiac outflow tract.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Semaphorin-3C, Semaphorin-E, Sema E, SEMAE, SEMA3C

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 713-768 of Human SEMA3C.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SEMA3C (E750) polyclonal antibody detects endogenous levels of SEMA3C protein.

Molecular Weight: ~ 85 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q99985

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only