Product Description

Semaphorin 4D Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11579-50, MB11579-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q92854

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 96 kDa; Observed MW: 120 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunocytochemistry analysis of Semaphorin 4D in Jurkat using Semaphorin 4D antibody, and DAPI., Western blot analysis of Semaphorin 4D/CD100 in Jurkat lysates using Semaphorin 4D/CD100 antibody.

Alternative Name: CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G

Immunogen: A synthetic peptide of human Semaphorin 4D

Conjugate: Unconjugated

Modification: Unmodified