SENP1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91220-50, BS91220-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9P0U3(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, ICC, IF, IHC, FC
All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Background: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: SENP1 polyclonal antibody detects endogenous levels of SENP1 protein.
Bioworld Molecular Weight: 73 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of SENP1 on K562 cell using anti-SENP1 antibody at 1/1,000 dilution., ICC staining SENP1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: SENP1, SENP 1, SENP1, SENP1, Sentrin specific protease 1, Sentrin-specific protease 1, Sentrin/SUMO specific protease 1, Sentrin/SUMO specific protease, Sentrin/SUMO specific protease SENP 1, Sentrin/SUMO specific protease SENP1, Sentrin/SUMO-specific protease SENP1, SUMO1/sentrin specific peptidase 1, SUMO1/sentrin specific protease 1, SuPr 2, SuPr2,
Immunogen: Recombinant protein within human SENP1 aa 300-500.
Conjugate: Unconjugated
Modification: Unmodified