SENP5 (L681) Polyclonal Antibody-BS1472

SENP5 (L681) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1472-50, BS1472-100

Sizes: 50µl, 100µl

Swiss-Prot: Q96HI0

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the “GG” region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SENP5 (L681) polyclonal antibody detects endogenous levels of SENP5 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of SENP5 (L681) pAb at 1:500 dilution
Lane 1: PC3 whole cell lysate (40ug)
Lane 2: MCF-7 whole cell lysate (40ug)
Lane 3: C6 whole cell lysate (40ug)
Lane 4: MEF whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of SENP5 (L681) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 87 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5; SENP5; FKSG45

Immunogen: Synthetic peptide, corresponding to amino acids 650-697 of Human SENP5.

Conjugate: Unconjugated

Modification: Unmodified