Septin 5 rabbit pAb - ES6638

Septin 5 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6638-50, ES6638-100

Citations, Manuals and MSDS Available upon request.

Background: septin 5 (SEPT5) Homo sapiens This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010],

Alternate Name: SEPT5; PNUTL1; Septin-5; Cell division control-related protein 1; CDCrel-1; Peanut-like protein 1

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from Septin 5 . at AA range: 180-260

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 42kD

Human Gene ID: 5413

Human SWISS Prot NO: Q99719

Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. In platelets, found in areas surrounding alpha-granules.

Research Use Only