Product Description

SERPINA6 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7868-50, BS7868-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The serine proteinase inhibitors (serpins) comprise a superfamily of proteins with a diverse set of functions, including the control of blood coagμlation, complement activation, programmed cell death and tissue development. SerpinA6, also known as CBG or Transcortin, is a 405 amino acid α-globμlin secreted protein that belongs to the serpin family. Synthesized in the liver and present in glycocorticoid responsive cells, SerpinA6 functions as the primary transport protein for progestins and glucorticoids within the blood. Additionally, SerpinA6 has corticosteroid-binding properties through which it can regμlate the physiological binding of serum cortisol within the cell. Defects in the gene encoding SerpinA6 are the cause of corticosteroid-binding globμlin deficiency (CBG deficiency), a rare disorder characterized by reduced corticosteroid-binding rates that resμlt in hypo/hypertension and muscle fatigue.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: CBG, CBG_HUMAN, corticosteroid binding globμlin, Corticosteroid-binding globμlin, serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6, Serpin A6, serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6, Serpina6, Transcortin,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human SERPINA6.

Dilution: WB 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SERPINA6 polyclonal antibody detects endogenous levels of SERPINA6 protein.

Molecular Weight: ~ 45 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P08185

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only