Product Description

SERPINA6 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7868-50, BS7868-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P08185

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB 1:500 - 1:2000

Background: The serine proteinase inhibitors (serpins) comprise a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and tissue development. SerpinA6, also known as CBG or Transcortin, is a 405 amino acid α-globulin secreted protein that belongs to the serpin family. Synthesized in the liver and present in glycocorticoid responsive cells, SerpinA6 functions as the primary transport protein for progestins and glucorticoids within the blood. Additionally, SerpinA6 has corticosteroid-binding properties through which it can regulate the physiological binding of serum cortisol within the cell. Defects in the gene encoding SerpinA6 are the cause of corticosteroid-binding globulin deficiency (CBG deficiency), a rare disorder characterized by reduced corticosteroid-binding rates that result in hypo/hypertension and muscle fatigue.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SERPINA6 polyclonal antibody detects endogenous levels of SERPINA6 protein.

Bioworld Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of SERPINA6 polyclonal antibody

Alternative Name: CBG;
CBG_HUMAN;
corticosteroid binding globulin;
Corticosteroid-binding globulin;
serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6;
Serpin A6;
serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6;
Serpina6;
Transcortin;

Immunogen: Recombinant full length Human SERPINA6.

Conjugate: Unconjugated

Modification: Unmodified