Product Description

SERTAD1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60410-50, BS60410-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regμlator interacting with the PHD-bromodomain 1), is a transcriptional regμlator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimμlating transcriptional activity. SEI-1 exists as a mμltiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regμlate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: SERTA domain-containing protein 1, CDK4-binding protein p34SEI1, SEI-1, Transcriptional regμlator interacting with the PHD-bromodomain 1, TRIP-Br1, SEI1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human SERTAD1.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SERTAD1 polyclonal antibody detects endogenous levels of SERTAD1 protein.

Molecular Weight: ~ 25 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UHV2

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only