SF3B1 (phospho-Thr313) rabbit pAb - ES13144

SF3B1 (phospho-Thr313) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES13144-50, ES13144-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Alternate Name: Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse

Immunogen: Synthesized phosho peptide around human SF3B1 (Thr313)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 145kD

Human Gene ID: 23451

Human SWISS Prot NO: O75533

Subcellular Location: Nucleus. Nucleus speckle. During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.

Research Use Only