Product Description

SFRP2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7759-50, BS7759-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The frizzled gene, originally identified in Drosophila melanogaster, was shown to be involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted, mammalian, frizzled-related proteins such as FRP-1 (also designated SARP2), FRP-2 (also designated SARP1), FRP-3, FRP-4 and SARP3 (also designated FRP-5), have been identified. The frizzled proteins contain seven transmembrane domains and a cysteine-rich domain in the extra carboxy-terminal Ser/Thr-xxx-Val motif, and they function as receptors for Wnt. The frizzled-1 gene maps to human chromosome 7q21 and is expressed in adμlt heart, placenta, lung, kidney, pancreas, prostate and ovary, as well as in fetal lung and kidney. Frizzled-2 is expressed in adμlt heart and fetal brain, lung and kidney. The frizzled-related proteins FRP-1, FRP-2, FRP-3, FRP-4 and SARP3 are secreted proteins that contain regions of homology to the cysteine-rich, ligand-binding domain of frizzled and a conserved, hydrophilic carboxy-terminus. The gene encoding human SARP3 maps to chromosome 4q31.3 and is expressed in retinal pigment epithelium (RPE) and pancreas, while expression of FRP-1, 2 and 4 is high in developing tissues. The FRPs/SARPs are involved in the Wnt signaling pathway by regμlating the intracellμlar levels of β-catenin.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Frizzled related protein 2, FRP 2, FRP-2, FRP2, MGC128911, MGC153618, MGC53344, SARP 1, SARP-1, SARP1, SDF 5, SDF5, Secreted apoptosis related protein 1, Secreted apoptosis-related protein 1, Secreted frizzled related protein 2, Secreted frizzled-related protein 2, sFRP 2, sFRP-2, SFRP2, Sfrp2 protein,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human SFRP2.

Dilution: WB: 1:500~1:2000
IHC/IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SFRP2 polyclonal antibody detects endogenous levels of SFRP2 protein.

Molecular Weight: ~ 26 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96HF1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only