SFRS8 Polyclonal Antibody-BS5952

SFRS8 Polyclonal Antibody

Catalogue Numbers: BS5952-50, BS5952-100

Sizes: 50µl, 100µl

Alternative Name: Splicing factor, suppressor of white-apricot homolog; Splicing factor, arginine/serine-rich 8; Suppressor of white apricot protein homolog; SFSWAP; SFRS8; SWAP

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q12872

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: SWAP (suppressor of white apricot protein homolog), also known as SFRS8 (splicing factor, arginine/serine-rich 8), is the 951 amino acid human homolog of a Drosophilia splicing protein. Localized to the nucleus, SWAP contains two SURP repeats through which it is thought to mediate splicing events, possibly regulating the alternative splicing of Fibronectin and CD45RC. SWAP regulates its own expression levels (via control of splicing in its first two introns) and may act in tandem with other arginine/serine-rich splicing factors to control protein expression. The gene encoding SWAP is located on a region of chromosome 12 that is related to asthma susceptibility, possibly indicating a role for SWAP in the development of asthma. Multiple isoforms of SWAP exist due to alternative splicing events.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SFRS8 polyclonal antibody detects endogenous levels of SFRS8 protein.

Bioworld Molecular Weight: ~ 105 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of SFRS8 polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: sp2/0 cell lysate
Lane 3: PC12 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 251-296 of Human SFRS8.

Conjugate: Unconjugated

Modification: Unmodified