Product Description

SGK (S422) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP0586-50, AP0586-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt. SGK is rapidly induced in response to a variety of stimμli, including serum, glucocorticoid, follicle stimμlating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modμlation of anti-apoptotic and cell cycle regμlation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regμlation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regμlated by ubiquitination and proteasome degradation.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regμlated kinase 1, SGK1, SGK, Serine/threonine-protein kinase Sgk2Serum/glucocorticoid-regμlated kinase 2, SGK2, Serine/threonine-protein kinase Sgk3, Cytokine-independent survival kinase, Serum/glucocorticoid-regμlated kinase 3, Serum/glucocorticoid-regμlated kinase-like, SGK3, CISK, SGKL

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human SGK.

Dilution: WB: 1:2000~1:5000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SGK (S422) polyclonal antibody detects endogenous levels of SGK protein.

Molecular Weight: ~ 58 kDa

Pathway: MTOR signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00141/Q9HBY8/Q96BR1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only