Product Description

SH2D4A Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61270-50, BS61270-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454 amino acid docking protein that belongs to the SH2 signaling protein family. Members of this family typically participate in intracellμlar signaling. Localizing to the cytoplasm, SH2D4A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. This suggests that SH2D4A, via its SH2 domain, may play an important function in cellμlar signal transduction. More specifically, SH2D4A is believed to function as an inhibiting factor in PKC signal transduction. In addition, SH2D4A exhibits abnormal expression in various cancers, implying that it may be involved in tumorigenesis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: SH2 domain-containing protein 4A, Protein SH(2)A, Protein phosphatase 1 regμlatory subunit 38, SH2D4A, PPP1R38, SH2A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human SH2D4A.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SH2D4A polyclonal antibody detects endogenous levels of SH2D4A protein.

Molecular Weight: ~ 52 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9H788

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only