Product Description

SHAN3 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA34841-50, RA34841-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SH3 and multiple ankyrin repeat domains 3 (SHANK3) Homo sapiens This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 191

Protein Molecular Weight (kDa): 191

Storage: -20°C/1 year

Human Gene ID: 85358

Human SwissProt Number: Q9BYB0

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only