Product Description

Shank 2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA29790-50, RA29790-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SH3 and multiple ankyrin repeat domains 2 (SHANK2) Homo sapiens This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: SHANK2, CORTBP1, KIAA1022, SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight: 135

Protein Molecular Weight (kDa): 135

Storage: -20°C/1 year

Human Gene ID: 22941

Human SwissProt Number: Q9UPX8

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only