Product Description

SHANK2 Polyclonal Antibody

Catalogue Numbers: BS62481-50, BS62481-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UPX8

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200

Background: The SHANK family proteins, also known as proline-rich synapse-associated proteins, consist of SHANK1, SHANK2, and SHANK3. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD), where they play a critical role in PSD assembly of excitatory synapses during development. While recruitment of SHANK proteins to the synapse is independent of their interaction with Homer, proper synaptic targeting of SHANK1 is mediated by interactions between its PDZ domain and PSD proteins. At the synapse, SHANK proteins interact with NMDA receptors and metabotropic glutamate receptor complexes. Research studies have proposed the involvement of SHANK proteins in autism and neurodegenerative diseases.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SHANK2 polyclonal antibody detects endogenous levels of SHANK2 protein.

Extra Notes: Western blot (WB) analysis of SHANK2 polyclonal antibody at 1:500 dilution
LaneA:A549 whole cell lysate
LaneB:HCT116 whole cell lysate
LaneC:CT26 whole cell lysate
LaneD:PC12 whole cell lysate

Bioworld Molecular Weight: ~ 135 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: SH3 and multiple ankyrin repeat domains protein 2; Shank2; Cortactin-binding protein 1; CortBP1; Proline-rich synapse-associated protein 1; SHANK2; CORTBP1; KIAA1022; PROSAP1

Immunogen: Synthetic peptide, corresponding to Human SHANK2.

Conjugate: Unconjugated

Modification: Unmodified