Product Description

SHANK2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65311-50, BS65311-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Swiss-Prot: Q9UPX8

Host: Rabbit

Reactivity: Human

Applications: WB, ELISA

All Applications: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Background: SH3 and multiple ankyrin repeat domains 2(SHANK2) Homo sapiens This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Shank 2 Polyclonal Antibody detects endogenous levels of Shank 2 protein.

Bioworld Molecular Weight: ~ 135 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of RAW264.7 cells using Shank 2 Polyclonal Antibody, Western blot analysis of lysates from RAW264.7, Jurkat, HepG2, and COLO cells, using SHANK2 Antibody. The Lane on the right is blocked with the synthesized peptide., Western blot analysis of the lysates from HT-29 cells using SHANK2 antibody.

Alternative Name: SHANK2; CORTBP1; KIAA1022; SH3 and multiple ankyrin repeat domains protein 2; Shank2; Cortactin-binding protein 1; CortBP1; Proline-rich synapse-associated protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human SHANK2. AA range:331-380

Conjugate: Unconjugated

Modification: Unmodified