Product Description

SHANK2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS77721-50, BS77721-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecμlar scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain mμltiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particμlar family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regμlating the molecμlar structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adμlt and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing resμlts in mμltiple transcript variants. [provided by RefSeq, Feb 2014]

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF/ICC

Alternate Names: AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, SHANK2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human SHANK2(NP_036441.2).

Dilution: WB, 1:500 - 1:2000 IF/ICC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 159kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UPX8

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only