Product Description

Shb (phospho-Y246) Polyclonal Antibody

Catalogue Numbers:BS4821-50, BS4821-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15464

Host: Rabbit

Reactivity: Human, Mouse

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell. Specifically, the SH2 domain targets SH2 domain-containing proteins to tyrosinephosphorylated sites, an event that can trigger a protein-protein interaction cascade which may ultimately effect gene expression and cellular function. Shb (SH2 domain-containing adapter protein b), Shd (SH2 domain-containing adapter protein d), She (SH2 domain-containing adapter protein e) and Shf(SH2 domain-containing adapter protein f) are SH2 domain-containing proteins that play various roles throughout the cell.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~55kDa

Specificity: p-Shb (Y246) polyclonal antibody detects endogenous levels of Shb protein only when phosphorylated at Tyr246.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: SH2 domain-containing adapter protein B; SHB

Immunogen: Synthetic phosphopeptide derived from human Shb around the phosphorylation site of Tyrosine 246.

Conjugate: Unconjugated

Modification: Phosphorylation