Product Description

SHC2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65264-50, BS65264-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: domain:The PID domain mediates binding to the TrkA receptor., function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons., miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576., PTM:Phosphorylated on tyrosines by the Trk receptors., similarity:Contains 1 PID domain., similarity:Contains 1 SH2 domain., subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2., tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: SHC2, SCK, SHCB, SHC-transforming protein 2, Protein Sck, SHC-transforming protein B, Src homology 2 domain-containing-transforming protein C2, SH2 domain protein C2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: Sck Polyclonal Antibody detects endogenous levels of Sck protein.

Molecular Weight: ~ 59 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P98077

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only