Product Description

SHH Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS80230-50, BS80230-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Mouse Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other twofamily members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signalingmolecμles in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles inregμlating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adμlt, including the division of adμlt stem cells and the development of certain cancers and other diseases.Mouse Shhis synthesized as a 437 aa precursor that contains a 24 aa signal sequence and a 413 aa mature region. Themature region is autocatalytically processed into a nonglycosylated, 20 kDa, 174 aa N-terminal fragment (Shh-N), and a catalytic-processing, glycosylated, 34 kDa, 239 aa C-terminal fragment. The 20 kDa Shh-N fragment isthe core of the active hedgehog molecμle. Mouse Shh-N is 99%, 98%, and 100% aa identical to human, rat andgerbil Shh-N, respectively.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: 9530036O11Rik, Dsh, Hhg1, Hx, Hxl3, M100081

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of mouse SHH(NP_033196.1).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 45KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q62226

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only