SHIP-1 (phospho Tyr1021) Polyclonal Antibody - RA29802

SHIP-1 (phospho Tyr1021) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29802-50, RA29802-100 Citations, Manuals and MSDS Available upon request. Background: inositol polyphosphate-5-phosphatase D (INPP5D) Homo sapiens This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5) -trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. A Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. Alternative Names: INPP5D; SHIP; SHIP1; Phosphatidylinositol 3; 4,5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; Applications: WB; ELISA Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 3635 Protein MW (KDa): 133 SWISS: Q92835 Source: Rabbit Research Use Only