SHIP-1 (phospho Tyr1021) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29802-50, RA29802-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: inositol polyphosphate-5-phosphatase D (INPP5D) Homo sapiens This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3, 4, 5)-trisphosphate and inositol-1, 3, 4, 5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. A Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, ELISA Alternate Names: INPP5D, SHIP, SHIP1, Phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1; Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. Molecular Weight: 133 Protein Molecular Weight (kDa): 133 Storage: -20°C/1 year Human Gene ID: 3635 Human SwissProt Number: Q92835 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only