SHP-1 (Phospho-Tyr564) Rabbit Polyclonal Antibody - BT-AP12654

SHP-1 (Phospho-Tyr564) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12654-20, BT-AP12654-50, BT-AP12654-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth| differentiation| mitotic cycle| and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains| which act as protein phospho-tyrosine binding domains| and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells| and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with| and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene| which encode distinct isoforms| have been reported.

Research Areas: Cancer; Cell biology; Developmental biology; Signal transduction

Target Protein: PTPN6

Applications: WB

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: SHP-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P29350; Mouse: P29351; Rat: P81718

Synonyms: SHP-1;Tyr564; Tyrosine-protein phosphatase non-receptor type 6; EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1

GeneID: Human: 5777; Mouse: 15170; Rat: 116689

Research Use Only