SHP-2 (Phospho-Tyr542) Rabbit Polyclonal Antibody - BT-AP12655

SHP-2 (Phospho-Tyr542) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12655-20, BT-AP12655-50, BT-AP12655-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth| differentiation| mitotic cycle| and oncogenic transformation. This PTP contains two tandem Src homology-2 domains| which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions| such as mitogenic activation| metabolic control| transcription regulation| and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Research Areas: Neuroscience; Signal transduction

Target Protein: PTPN11

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: SHP-2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q06124; Mouse: P35235; Rat: P41499

Synonyms: SHP-2;Tyr542; Tyrosine-protein phosphatase non-receptor type 11; EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3

GeneID: Human: 5781; Mouse: 19247; Rat: 25622

Research Use Only