Siah-1/2 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29820-50, RA29820-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: siah E3 ubiquitin protein ligase 1 (SIAH1) Homo sapiens This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008], Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, IHC-p, IF/ICC, ELISA Alternate Names: SIAH1, HUMSIAH, E3 ubiquitin-protein ligase SIAH1, Seven in absentia homolog 1, Siah-1, Siah-1a, SIAH2, E3 ubiquitin-protein ligase SIAH2, Seven in absentia homolog 2, Siah-2, hSiah2 Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. Molecular Weight: 34 Protein Molecular Weight (kDa): 34 Storage: -20°C/1 year Human Gene ID: 6477/6478 Human SwissProt Number: Q8IUQ4/O43255 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only