Siah-1/2 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29820-50, RA29820-100 Citations, Manuals and MSDS Available upon request. Background: siah E3 ubiquitin protein ligase 1 (SIAH1) Homo sapiens This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. Alternative Names: SIAH1; HUMSIAH; E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1; Siah-1; Siah-1a; SIAH2; E3 ubiquitin-protein ligase SIAH2; Seven in absentia homolog 2; Siah-2; hSiah2 Applications: WB; IHC-p; IF/ICC; ELISA Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 6477/6478 Protein MW (KDa): 34 SWISS: Q8IUQ4/O43255 Source: Rabbit Research Use Only