Product Description

SIP1 (E101) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3009-50, BS3009-100

Sizes: 50µl, 100µl

Swiss-Prot: O60315

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC

Background: SIP1, also known as SMADIP1 and ZFHX1B, can be induced by TGFβ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SIP1 (E101)pAb detects endogenous levels of SIP1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of SIP1 (E101) polyclonal antibody at 1:500 dilution
Lane 1: Hela whole cell lysate
Lane 2: HEK293T whole cell lysate
Lane 3: NIH-3T3 whole cell lysate, Immunohistochemistry (IHC) analyzes of SIP1 (E101) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 157 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b; ZEB2; KIAA0569; SIP1; ZFHX1B; ZFX1B; HRIHFB2411

Immunogen: Synthetic peptide, corresponding to amino acids 71-120 of Human SIP1.

Conjugate: Unconjugated

Modification: Unmodified