Product Description

SIRT2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP0019-50, AP0019-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SIRT2 is a member of the sirtuin family of proteins. Studies suggest that the human sirtuins may function as intracellμlar regμlatory proteins with mono-ADP-ribosyltransferase activity. SIRT2 interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. SIRT2 is a NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubμlin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regμlation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: NAD-dependent protein deacetylase sirtuin-2, Regμlatory protein SIR2 homolog 2, SIR2-like protein 2, SIRT2, SIR2L, SIR2L2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 330-380 of Human SIRT2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SIRT2 polyclonal antibody detects endogenous levels of SIRT2 protein.

Molecular Weight: ~ 43 kDa

Pathway: Mitochondrial Control of Apoptosis, Epigenetic Writers and Erasers of Histone H3, Epigenetic Writers and Erasers of Histones H2A H2B and H4,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8IXJ6

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only