SIRT5 Polyclonal Antibody-BS91247

SIRT5 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91247-50, BS91247-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9NXA8(Human) Q8K2C6(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB:1:1,000-1:2,000

Background: SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SIRT5 on Jurkat cellsLysates using anti-SIRT5 antibody at 1/1,000 dilution.

Bioworld Molecular Weight: 37/22 kDa

Specificity: SIRT5 polyclonal antibody detects endogenous levels of SIRT5 protein.

Alternative Name: SIRT5, NAD dependent deacetylase sirtuin 5, NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial, NAD dependent protein deacylase sirtuin 5 mitochondrial, NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5, Silent mating type information regulation 2 S.cerevisiae homolog 5, Sir2 like 5, SIR2-like protein 5, SIR2L5, SIR5, Sirt5, Sirtuin 5, Sirtuin type 5,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified