SIRT5 Rabbit Polyclonal Antibody - RA36915

SIRT5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36915-50, RA36915-100

Citations, Manuals and MSDS Available upon request.

Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically
removes malonyl, succinyl and glutaryl groups on target proteins . Activates CPS1 and
contributes to the regulation of blood ammonia levels during prolonged fasting: acts by
mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting . Activates SOD1 by mediating its
desuccinylation, leading to reduced reactive oxygen species . Activates SHMT2 by
mediating its desuccinylation . Modulates ketogenesis through the desuccinylation and
activation of HMGCS2 (By similarity) . Has weak NAD-dependent protein deacetylase
activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: SIRT5 SIR2L5

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 23408

Protein MW (KDa): 34

SWISS: Q9NXA8

Source: Rabbit

Research Use Only