Product Description

SIRT5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36915-50, RA36915-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically
removes malonyl, succinyl and glutaryl groups on target proteins . Activates CPS1 and
contributes to the regulation of blood ammonia levels during prolonged fasting: acts by
mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting . Activates SOD1 by mediating its
desuccinylation, leading to reduced reactive oxygen species . Activates SHMT2 by
mediating its desuccinylation . Modulates ketogenesis through the desuccinylation and
activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase
activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: SIRT5 SIR2L5

Clonality: Polyclonal

Dilution: WB 1:500-2000

Molecular Weight: 34

Protein Molecular Weight (kDa): 34

Storage: -20°C/1 year

Human Gene ID: 23408

Human SwissProt Number: Q9NXA8

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Use Only