Product Description

SKI-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA29848-50, RA29848-100

Citations, Manuals and MSDS Available upon request.

Background: membrane bound transcription factor peptidase, site 1 (MBTPS1) Homo sapiens This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Alternative Names: MBTPS1; KIAA0091; S1P; SKI1; Membrane-bound transcription factor site-1 protease; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 8720

Protein MW (KDa): 130

SWISS: Q14703

Source: Rabbit

Research Use Only