SLAP Polyclonal Antibody-BS65766

SLAP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65766-50, BS65766-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: Q13239

Host: Rabbit

Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,

Applications: WB

All Applications: WB=1:500-2000

Background: The Src homology 3 (SH3) region is a small protein domain of approximately 60 amino acids present in a large group of proteins. In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-? within structural proteins, such as spectrin or Myosin; and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids, which bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. The functions of SH3 domains are not as well defined. Deletion or mutation of SH3 domains generally activate the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. 3BP1 has been identified as a protein with a high affinity proline-rich binding site for the SH3 domain of c-Abl p120. A similar putative adapter protein, designated Slap, for Src-like adapter protein, has been cloned. Slap contains a single SH2 and SH3 domain that exhibits homology with those from members of the Src kinase family. The N- and C-termini, however, are unique.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SLAP Polyclonal Antibody detects endogenous levels of SLAP protein.

Bioworld Molecular Weight: 33 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti- SLAP at 1/1000 dilution

Alternative Name: hSLAP; SLA 1; SLA; SLA1; SLAP 1; SLAP; SLAP-1; SLAP1; SLAP1_HUMAN; Src like adapter; Src like adapter protein 1; Src like adaptor; SRC-like-adapter; Src-like-adapter protein 1.聽聽

Immunogen: KLH conjugated synthetic peptide derived from human SLAP:21-120/276

Conjugate: Unconjugated

Modification: Unmodified