Product Description

SLC16A5 (A193) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP0702-50, AP0702-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Monocarboxylates, such as lactate and pyruvate, play an integral role in cellμlar metabolism. Lactic acid is produced in large quantities as a resμlt of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumμlation of lactic acid leads to a decrease in intracellμlar pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT6 is highly expressed in the kidneys and is thought to have a specificity for bumetanide, a loop diuretic involved in the treatment of edema. The high substrate specificity of MCT6 suggests a possible role in therapeutic drug transport and trafficking across the plasma membrane.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Monocarboxylate transporter 6, MCT 6, Monocarboxylate transporter 5, MCT 5, Solute carrier family 16 member 5, SLC16A5, MCT5, MCT6

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 161-210 of Human SLC16A5.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: SLC16A5 (A193) polyclonal antibody detects endogenous levels of SLC16A5 protein.

Molecular Weight: ~ 55 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15375

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only