SLC22A3 (Q306) Polyclonal Antibody-BS3359

SLC22A3 (Q306) Polyclonal Antibody

Catalogue Numbers: BS3359-50, BS3359-100

Sizes: 50µl, 100µl

Alternative Name: Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; SLC22A3; EMTH; OCT3

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O75751

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT3, also known as extraneuronal monoamine transporter, is widely expressed in different regions of the brain including the hippocampus, cerebellum and cerebral cortex. OCT3 mediates the uptake of several neuroactive agents, including dopamine, and may play an important role in the disposition of neurotransmitters and cationic neurotoxins in the brain.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SLC22A3 (Q306) polyclonal antibody detects endogenous levels of SLC22A3 protein.

Bioworld Molecular Weight: ~ 61 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of SLC22A3 (Q306) polyclonal antibody at 1:500 dilution
Lane 1: 786-O whole cell lysate(40ug)
Lane 2: L02 whole cell lysate(40ug)
Lane 3: HEK293T whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 281-330 of Human SLC22A3.

Conjugate: Unconjugated

Modification: Unmodified