SMAC Monoclonal Antibody-MB11607

SMAC Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11607-50, MB11607-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9NR28

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-F, IHC-P, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20

Background: Smac/Diablo is a 21 kDa mammalian mitochondrial protein that functions as a regulatory component during apoptosis. Upon mitochondrial stress, Smac/Diablo is released from mitochondria and competes with caspases for binding of IAPs (inhibitor of apoptosis proteins). The interaction of Smac/Diablo with IAPs relieves the inhibitory effect of the IAPs on caspases.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 27 kDa; Observed MW: 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Smac/Diablo in mouse heart, rat skin lysates using SMAC antibody., Western blot analysis of Smac/Diablo in K562, Hela lysates using Smac/Diablo antibody., Immunocytochemistry analysis of Smac/Diablo in Hela using Smac/Diablo antibody, and DAPI, Immunohistochemistry analysis of paraffin-embedded Human tonsil using Smac/Diablo antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: SMAC; DFNA64; DIABLO; SMAC3

Immunogen: A synthetic peptide of human Smac/Diablo

Conjugate: Unconjugated

Modification: Unmodified