Smad1 (Phospho Ser214) rabbit pAb - ES20159

Smad1 (Phospho Ser214) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20159-50, ES20159-100

Citations, Manuals and MSDS Available upon request.

Background: function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD)., PTM:Phosphorylated on serine by BMP type 1 receptor kinase., PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1., similarity:Belongs to the dwarfin/SMAD family., similarity:Contains 1 MH1 (MAD homology 1) domain., similarity:Contains 1 MH2 (MAD homology 2) domain., subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4., subunit:Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1., tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.,

Alternate Name: Mothers against decapentaplegic homolog 1 (MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1)

Source: Rabbit

Applications: WB; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human Smad1 (Phospho Ser214)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 51kD

Human Gene ID: 4086

Human SWISS Prot NO: Q15797

Subcellular Location: Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity).

Research Use Only