Smad1 (Phospho Ser214) Rabbit Polyclonal Antibody - RA29876

Smad1 (Phospho Ser214) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA29876-50, RA29876-100

Citations, Manuals and MSDS Available upon request.

Background: function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) .,PTM:Phosphorylated on serine by BMP type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Interacts with HGS, NANOG and ZCCHC12 (By similarity) . May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.,tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.,

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000 ELISA 1:5000-20000

Alternative Names: Mothers against decapentaplegic homolog 1 (MAD homolog 1;Mothers against DPP homolog 1;JV4-1;Mad-related protein 1;SMAD family member 1;SMAD 1;Smad1;hSMAD1;Transforming growth factor-beta-signaling protein 1;BSP-1)

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 4086

Protein MW (KDa): 51

SWISS: Q15797

Source: Rabbit

Research Use Only