Smad2/3 (Acetyl-Lys19) Polyclonal Antibody - BT-AP07997

Smad2/3 (Acetyl-Lys19) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07997-20, BT-AP07997-50, BT-AP07997-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the SMAD| a family of proteins similar to the gene products of the Drosophila gene andapos;mothers against decapentaplegicandapos; (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta| and thus regulates multiple cellular processes| such as cell proliferation| apoptosis| and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal| this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation

Research Areas: Epigenetics and nuclear signaling; Signal transduction; Metabolism; Cancer; Stem cells

Target Protein: Smad2/3

Applications: IHC-p, IF, WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Smad2/3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q15796/P84022

Synonyms: Smad2/3;Acetyl-Lys19

GeneID: Human: 4088/4087

Research Use Only